(ORC patent and paper publication in 2025)

(2025)獲證專利 (Certified patent) 2

1.       台灣專利案『一種骨釘螺孔定位裝置』 / 專利證號:I866799 (高醫編號:111002-TW)2024.12.11通知獲證 (傅尹志、蘇宇喬、李天慶、王彥雄、何美泠、陳崇桓、高俐婷)

2.       台灣專利案『預防或治療骨關節炎的凝血調節速與miRNA (中華民國案號:113116868)2025.12.05通知獲證 (鄭琮霖、陳崇桓、張瑞根)

(2025) Publication 38

1.       The future of osteoarthritis treatment: exploring the potential of exosomes from adipose tissue-derived stem cells : a scoping review (Pin-Han Huang, Sung-Yen Lin, Chung-Hwan Chen, Yin-Chih Fu, Tien-Ching Lee) Bone & Joint Research, 2025 Dec 4;14(12):1092-1108

2.       Real-world persistence and compliance of denosumab versus alendronate among postmenopausal women with osteoporosis in Asia-Pacific (Tang Ching Lau, Dong-Gune Chang, Chung-Hwan Chen, et al.) J Bone Miner Metab., 2025 Nov 19

3.       Letter to the Editor: Factors That Increase the Risk of Prosthetic Joint Infection Within 90 Days After THA and TKA: A Nationwide Population-based Study (Szu-An Jou, Chia-Hao Hsu) Clinical Orthopaedics and Related Research, 2025 Dec 8

4.       Reconsidering Patellofemoral Outcomes in Medially Stabilized Total Knee Arthroplasty: The Role of Implant Design and Rotational Strategy in Kinematic Alignment (Chia-Hao Hsu) Arthroplasty Today, 2025 Nov 3:36:101895

5.       Letter Regarding “Risk of Early Manipulation in Cemented versus Cementless Total Knee Arthroplasty: An Analysis of the American Joint Replacement Registry” (Chia-Hao Hsu) Journal of Arthroplasty, 2025 Dec;40(12):e79-e80

6.       Reevaluating periarticular injection for pain control in total knee arthroplasty (Tien-Yu Fu, Chia-Hao Hsu) Knee, 2025 Nov 15:S0968-0160(25)00270-4

7.       Letter regarding "High Altitude Is an Independent Risk Factor for Postoperative Venous Thromboembolism Following Primary Total Knee Arthroplasty: A Large Database Study" (Tien-Ching Lee) Journal of Arthroplasty, 2025 May;40(5):e40-e41

8.       Letter to the Editor: Standardized Intraoperative Robotic Laxity Assessment in TKA Leads to No Clinically Important Improvements at 2 Years Postoperatively: A Randomized Controlled Trial (Yu-Hsien Chen, Chia-Hao Hsu) Clinical Orthopaedics and Related Research, 2025 Oct 9

9.       Roles of basic fibroblast growth factor, stem cells from dental pulp and apical papilla in the repair and regeneration of dental pulp and other tissues/organs (Pin-Hsuan Wu, Yan-Hsiung Wang, et al.) Journal of Dental Sciences, 2025 Oct;20(4):2066-2075

10.  Impact of Time Since Diagnosis and Age on Fracture Risk in Young Adults With Type 1 and Type 2 Diabetes (Tien-Ching Lee, Sung-Yen Lin, Chung-Hwan Chen, Pei-Shan Ho) Kaohsiung Journal of Medical Sciences, 2025 Sep 27:e70112

11.  Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis (Yu-Chuan Chan, Jian-Chih Chen, Sung-Yen Lin, et al.) Kaohsiung Journal of Medical Sciences, 2025 Oct 9:e70124

12.  Amelioration of Post-traumatic Osteoarthritis by Iontophoretic Liposomal Strontium Ranelate Collaborated with Low-Intensity Pulsed Ultrasound in Rats (Chung-Hwan Chen, Syu-Lun Lin, et al.) International Journal of Molecular Sciences, 2025 Sep 10;26(18):8815

13.  Letter Regarding “Increased Waist Circumference Is Associated With Severe Postoperative Medical Complications Following Total Knee Arthroplasty: Understanding Waist Circumference and Relation to Body Mass Index” (Yu-Hsien Chen, Chia-Hao Hsu) Journal of Arthroplasty, 2025 Nov;40(11):e69-e70

14.  Umbilical cord mesenchymal stem cells derived extracellular vesicles enhance chondrocyte function by reducing oxidative stress in chondrocytes (Che-Wei Wu, Yao-Hui Huang, et al.) International Journal of Molecular Sciences, 2025 Aug 8;26(16):7683

15.  Cohort Profile: Taiwan Kidney Outcome (TAKO) and Taiwan Kidney Outcome Omics (TAKOO) cohorts (Ping-Hsun Wu, Ming-Yen Lin, et al.) International Journal of Epidemiology, 2025 Aug 18;54(5):dyaf152

16.  Effect of human adipose stem cell-derived mitochondrial transplantation on the activity of chronically injured anterior cruciate ligament cells (Hon Lok Lo, Yao-Hui Huang, et al.) Bone Joint Res, 2025 Sep 19;14(9):805-819

17.  Letter to the Editor: To What Degree Do Patients' and Clinicians' Ratings of Appropriateness of TKA Align, and Were Expected Outcomes Associated With Those Ratings? (Chia-Hao Hsu) Clinical Orthopaedics and Related Research, 2025 Sep 3

18.  Clinical impact of pharmacogenetic risk variants in a large chinese cohort (Chun-Yu Wei, Ming-Shien Wen, et al.) Nat Commun, 2025 Jul 9;16(1):6344

19.  Empagliflozin protected kidney function in CKD rat through suppressing hypoxic and fibrotic signalings mediated inflammation and EMT (Chih-Chao Yang, Jui-Ning Yeh, et al.) Histol Histopathol, 2025 Jun 18:18953

20.  miR-708-5p Attenuates Osteoarthritis Progression via Multi-Target Modulation of the NOX4/NF-κB Axis and Cartilage Homeostasis (Shih-Hao Huang, Zi Miao Liu, et al.) Cartilage, 2025 Jul 30:19476035251361679

21.  Empagliflozin protected kidney function in CKD rat through suppressing hypoxic and signalings mediated inflammation and EMT (Chih-Chao Yang, Jui-Ning Yeh, et al.) Histol Histopathol, 2025 Jun 18:18953

22.  Engagement and Stress Concentration Evaluation of a Novel Two-Part Compression Screw: A Preliminary Finite Element Analysis (Chia-Hao Hsu, Chih-Kuang Wang, et al.) Bioengineering (Basel), 2025 May 1;12(5):483

23.  Modification of a Two-Part Cancellous Locking Screw: A Pilot Study on Increasing Resistance to Axial Pullout Strength (Chia-Hao Hsu, Nin-Chieh Hsu, et al.) Bioengineering (Basel), 2025 Apr 23;12(5):444

24.  Roles of basic fibroblast growth factor, stem cells from dental pulp and apical papilla in the repair and regeneration of dental pulp and other tissues/organs (Pin-Hsuan Wu, Yan-Hsiung Wang, et al.) Journal of Dental Sciences, Available online 29 May 2025

25.  Novel minimally invasive carpal tunnel release using a specialized surgical kit: a prospective multi-center case series (Hsuan-Fu Chen, Shun-Min Chang, et al.) BMC Musculoskelet Disord, 2025 Apr 8;26(1):346

26.  Asia-Pacific consensus for the management of osteoporosis in men (Chun-Feng Huang, Cheng-Jung Ho, Chung-Hwan Chen, et al.) Osteoporos Int Osteoporos Int . 2025 Jul;36(7):1105-1114.

27.  Skyline view versus intraoperative 3D fluoroscopy for dorsal screw protrusion identification following volar plating in the treatment of distal radial fracture (Chih-Hsuan Wung, Wen-Chih Liu, et al.) J Orthop Surg Res, 2025 Feb 22;20(1):190

28.  Comparisons of miRNA profiles of exosomes derived from human iPSCs, ADSCs and BMSCs and effects on chondrocyte function (Ling-Hua Chang, Shu-Chun Chuang, Chung-Hwan Chen, Mei-Ling Ho, et al.) Bone & Joint Research Bone Joint Res. 2025 Aug 18;14(8):696-712

29.  Psychometric Properties of the QuickDASH in Patients with Neck Pain (Lue YJ, Cheng KI, Lin CL, Chen CH, Lu YM) J Clin Med., 2025 Feb 14;14(4):1266

30.  Association studies of vasoactive genes and preeclampsia in taiwan (Yang ML, Chang FM, Wu MH, Chen CH, Cheng TL, Kang L) Placenta, 2025 Mar 6;161:14-22

31.  Comment on 'Beyond the scoreboard: Coaches' UV-related skin cancer knowledge in outdoor sports' (Luo-Wei Chan, Shih-Hao Huang, Jian-Chih Chen, Chia-Hao Hsu) J Eur Acad Dermatol Venereol., 2025 Feb 6

32.  Cell Cycle Interruption and Apoptosis Induction by Dinaciclib in Oral Squamous Cell Carcinoma: Mechanistic Insights and Therapeutic Potential (Muhammet Oner, Yu-Chiao Cheng, Yan-Hsiung Wang, et al.) International Journal of Molecular Sciences (Accepted)

33.  G-protein-coupled estrogen receptor-1 facilitates chondrocyte proliferation in pubertal epiphyseal growth plate via PTHrP/Ihh regulation (Ya-Shuan Chou, Sung-Yen Lin, Chung-Hwan Chen, Mei-Ling Ho, Je-Ken Chang) Bone & Joint Research, 2025 Jul 1;14(7):589-600

34.  Silanized acrylic graphene oxide nanocomposite reinforced mechanically tunable GelMA/HAMA printable bio-ink for adipose-derived stem cells differentiated mature smooth muscle cells (Pavanchandh Atturu, Su-Shin Lee, Chih-Kuang Wang, et al.) Biomaterials Advances, Available online 6 February 2025, 214226

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