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Gwo-Jaw Wang
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現任：
• 美國維吉尼亞大學 名譽教授
• 國立成功大學 榮譽教授
• 高雄醫學大學 骨科學 客座教授
• 高雄醫學大學 附院骨科 主治醫師
• 全球華裔骨科學會 理事長
經歷：
• 美國維吉尼亞大學 骨科 教授
• 美國維吉尼亞大學 骨科 講座教授
• 美國維吉尼亞大學 骨科 主任
• 美國維吉尼亞大學 骨科 總醫師
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學歷：
• 高雄醫學院 醫學系
專長：
• 骨科學
• 膝及髖關節置換及治療
• 骨壞死治療
• 消炎藥物對骨及軟骨細胞功能之研究
• 骨質壞死症之研究
• 骨質疏鬆症之研究
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退化性關節炎之研究
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五年內論文發表：
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- Jyun-Yi Wu, Yan-Hsiung Wang, Gwo-Jaw Wang, Mei-Ling Ho, Chau-Zen Wang, Ming-Long Yeh, Chia-Hsin Chen.
Low-Power GaAlAs Laser Irradiation Promotes the Proliferation and Osteogenic Differentiation of Stem Cells via IGF1 and BMP2.
PLoS ONE (under review)
- Sun-Chun Chuang, Je-Ken Chang, Rajalakshmanan Eswaramoorthy, Gwo-Jaw Wang, Mei-Ling Ho*
Hyaluronan initiates chondrogenesis mainly via CD44 in human adipose derived stem cells.
Stem Cells and Development (submitted in Feb, 2012)
- Rajalakshmanan Eswaramoorthy, Chia-Chi Chang, Shun-Cheng Wu, Gwo-Jaw Wang, Je-Ken Chang, Mei-Ling Ho*
Sustained release of PTH(1-34) from PLGA microspheres suppresses osteoarthritis progression in rats.
Acta Biomaterialia (accepted in Mar, 2012) (IF: 4.824 in 2010; Ranking:3/70 in ENGINEERING, BIOMEDICAL; 3/25 in MATERIALS SCIENCE, BIOMATERIALS)
- Hui-Ting Chen, Mon-Juan Lee, Chung-Hwan Chen, Shu-Chun Chuang, Mei-Ling Ho, Shao-Hung Hung, Yin-Chih Fu, Yan-Hsiung Wang, Hsin-I Wang, Gwo-Jaw Wang, Lin Kang, Je-Ken Chang * (#These authors contributed equally to this manuscript. )
Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures.
Journal of Cellular and Molecular Medicine 2012 Mar; 16(3): 582-593 (IF: 4.608 in 2010; ranking: 59/177 in CELL BIOLOGY; 18/106 in MEDICINE, RESEARCH & EXPERIMENTAL)
- Chung-Hwan Chen, Je-Ken Chang, Kuo-An Lai, Sheng-Mou Hou, Chih-Hao Chang, Gwo-Jaw Wang.
Alendronate in the prevention of collapse of the femoral head in non-traumatic osteonecrosis (a randomized, multicenter, double-blind study).
Arthritis and Rheum. 2011 Nov 29. (Impact factor: 8.435 in 2010; Ranking: 2/29 in RHEUMATOLOGY ) [Epub ahead of print].
- Chih-Hua Tseng, Ru-Wei Lin, Yeh-Long Chen, Gwo-Jaw Wang, Mei-Ling Ho, Cherng-Chyi Tzeng*.
Discovery of Indeno[1,2-c]quinoline Derivatives as Inhibitors of Osteoclastogenesis Induced by Receptor Activator of NF-kappa B Ligand (RANKL).
JOURNAL OF MEDICINAL CHEMISTRY 54(8) 3103-3107 Apr-28 2011 (IF: 5.207 in 2010 ; ranking: 3/54 in CHEMISTRY, MEDICINAL)
- Ching-Ju Li, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho*
Constitutively Expressed COX-2 in Human Osteoblasts Positively Regulates Akt Signal Transduction via Suppression of PTEN Activity
Bone 2011 Feb 1;48(2):286-97 (IF: 4.601 in 2010 ; ranking: 26/116 in ENDOCRINOLOGY & METABOLISM)
- Ching-Ju Li, Je-Ken Chang, Chia-Hsuan Chou, Gwo-Jaw Wang, Mei-Ling Ho*
The PI3K/AKT/FOXO-3a/p27kip1 signaling contributes to anti-inflammatory drug-suppressed proliferation of human osteoblasts.
Biochemical Pharmacology volume 79 issue 6 (2010 Oct.) 926–937 (SCI) (IF: 4.254 in 2009 ; ranking: 34/236 in PHARMACOLOGY & PHARMACY)
- Chau-Zen Wang, Gwo-Jaw Wang, Mei-Ling Ho, Yan-Hsiung Wang, Yen-Hui Chang, and Chia-Hsin Chen*
Low-magnitude vertical vibration enhances myotube formation in C2C12 myoblasts.
Journal of Applied Physiology 2010 Sep;109(3):840-8 (SCI) (IF: 3.732 in 2009; Ranks: 1/72 in Sport Sciences; 17/75 in PHYSIOLOGY)
- Chau-Zen Wang, Shih-Mao Chen, Chung-Hwan Chen, Chih-Kuang Wang, Gwo-Jaw Wang, Je-Ken Chang*,
Mei-Ling Ho*
The Effect of the Local Delivery of Alendronate on Human Adipose-Derived Stem Cell-Based Bone Regeneration
Biomaterials 31 (2010 Aug) 8674-8683 (IF: 7.365 in 2009 ; ranking: 1/25 in MATERIALS SCIENCE, BIOMATERIALS; ranking:2/59 in ENGINEERING, BIOMEDICAL)
- Shun-Cheng Wu, Je-Ken Chang, Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho*
Enhancement of Chondrogenesis of Human Adipose Derived Stem Cells in a Hyaluronan-Enriched Microenvironment
Biomaterials 2010 Feb;31(4):631-40 (IF: 7.365 in 2009 ; ranking: 1/25 in MATERIALS SCIENCE, BIOMATERIALS; ranking:2/59 in ENGINEERING, BIOMEDICAL)
- Chih-Hua Tseng, Yeh-Long Chen, Chih-Ming Lu, Chih-Kuang Wang, Yin-Tung Tsai, Ru-Wei Lin, Chain-Fu Chen, Yu-Fang Chang, Gwo-Jaw Wang, Mei-Ling Ho*, Cherng-Chyi Tzeng*
Synthesis and anti-osteoporotic evaluation of certain 3-amino-2- hydroxypropoxyisoflavone derivatives.
European Journal of Medicinal Chemistry 2009 Sep;44(9):3621-6 (SCI) (IF:2.882 in 2008; Ranking:13/41 in CHEMISTRY, MEDICINAL)
- Ching-Hua Yeh, Je-Ken Chang, Mei-Ling Ho, Chung-Hwan Chen, Gwo-Jaw Wang*
Different Differentiation of Stroma Cells From Patients With Osteonecrosis.
Clin Orthop Relat Res 2009 Aug;467(8):2159-67 (SCI)(IF:1.893 in 2008; Ranking:16/49 in ORTHOPEDICS; 48/148 in SURGERY)
- Je-ken Chang, Ling-Hwa Chang, Shao-Hung Hung, Sheng-Cheng Wu, Hsin-Yi Lee, Yi-Shan Lin, Chung-Hwan Chen, Yin-Chih Fu, Gwo-Jaw Wang, Mei-Ling Ho*
Parathyroid Hormone (1-34) Inhibits Terminal Differentiation of Human Articular Chondrocytes and Osteoarthritis Progression in Rats.
Arthritis and Rheumatism 2009; 60; 3049-3060 (SCI)(IF:6.787 in 2008; Ranking:2/22 in RHEUMATOLOGY)
- Chih-Kuang Wang, Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Chung-Hwan Chen, Yin-Chih Fu*, Hwai-Hui Fu
Controlled-release of rhBMP-2 carriers in the regeneration of osteonecrotic bone.
Biomaterials 30 (2009), pp. 4178-4186 (SCI) (IF: 6.646 in 2008 ; ranking: 1/20 in MATERIALS SCIENCE, BIOMATERIALS; ranking:2/52 in ENGINEERING, BIOMEDICAL)
- Je-Ken Chang, Ching-Ju Li, Hsiu-Jun Liao, Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho*
Anti-inflammatory drugs suppress proliferation and induce cell death through altering expressions of regulators of cell cycle and apoptosis in cultured human osteoblasts.
Toxicology 258(2009) 148-156 (SCI)(IF:2.836 in 2008; Ranking:20/75 in TOXICOLOGY; 73/219 in PHARMACOLOGY & PHARMACY)
- Ru-Wei Lin, Chung-Hwan Chen, Yan-Hsiung Wang, Mei-Ling Ho, Shao-Hung Hung, Ih-Sheng Chen,
Gwo-Jaw Wang*
(-)-Epigallocatechin gallate inhibition of osteoclastic differentiation via NF-<kappa>B.
Biochemical and Biophysical Research Communications (2009) 379(4) 1033–1037 (SCI)(IF: 2.648 in 2008 ; Ranking: 134/275 in BIOCHEMISTRY & MOLECULAR BIOLOGY; 28/71 in BIOPHYSICS)
- Mei-Ling Ho, Yi-Hui Chen, Hsiu-Jung Liao, Chung-Hwan Chen, Shao-Hung Hung, Mon-Juan Lee, Yin-Chih Fu, Yan-Hsiung Wang, Gwo-Jaw Wang, Je-Ken Chang*
Simvastatin increases osteoblasts and osteogenic proteins in ovariectomized rats.
European Journal of Clinical Investigation 2009; 39 (4): 296–303 (SCI) (IF:2.784 in 2008; Ranking:23/107 in MEDICINE, GENERAL & INTERNAL)
- Yan-Hsiung Wang, Mei-Ling Ho, Je-Ken Chang, Hai-Chang Chu, Shu-Chin Lai, Gwo-Jaw Wang*
Microporation a valuable transfection method for gene expression in human adipose tissue-derived stem cells.
Molecular Therapy 2009 Feb;17(2):302-8. (IF:5.97 in 2008; Ranking:10/144 in BIOTECHNOLOGY & APPLIED MICROBIOLOGY; 17/138 in GENETICS & HEREDITY; 6/83 in MEDICINE, RESEARCH & EXPERIMENTAL)
- Shao-Hung Hung, Ching-Hua Yeh, Hsuan-Ti Huang, Peihua Wu, Mei-Ling Ho, Chung-Hwan Chen*, Chihuei Wang*, David Chao, Gwo-Jaw Wang
Pioglitazone and Dexamethasone Induce Adipogenesis in D1 Bone Marrow Stromal Cell Line, but not through the PPARγ Pathway.
Life Sciences 82 (2008) 561-569 (SCI) (Impact factor:2.389 Rank:28/76; Rank:79/199)
- Mei-Ling Ho, Yin-Chih Fu, Gwo-Jaw Wang, Hui-Ting Chen, Je-Ken Chang, Tsung-Hsien Tsai, Chih-Kuang Wang*
Controlled release carrier of BSA made by W/O/W emulsion method containing PLGA and hydroxyapatite.
Journal of Controlled Release 128(2008) 142-148 (SCI) (IF: 4.756 in 2007 ; ranking:14/127=11% in CHEMISTRY, MULTIDISCIPLINARY)
- Ching-Hua Yeh, Je-Ken Chang, Yan-Hsiung Wang, Mei-Ling Ho, Gwo-Jaw Wang*
Ethanol May Suppress Wnt/β-catenin Signaling on Human Bone Marrow Stroma Cells: A Preliminary Study.
Clin Orthop Relat Res 2008 466(5):1047-53 (SCI)(IF:1.891; Ranking:41/139; 11/48)
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近期研討會論文發表： |
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- Shu-Chun Chuang, Li Fu Chang, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang
Estrogen receptor and GRP30 contribute to simvastatin-stimulated osteogenic effects on murine bone marrow mesenchymal stem cells.
2012 Annual Meeting of the Orthopaedic Research Society, San Francisco, USA, Feb 4-7, 2012.
- Shu-Chun Chuang, Ching-Ju Li, Gwo-Jaw Wang, Je-Ken Chang, Mei-Ling Ho
Cycloxygenase-2 contributes to osteogenic-differentiation on murine bone marrow mesenchymal stem cells.
2012 Annual Meeting of the Orthopaedic Research Society, San Francisco, USA, Feb 4-7, 2012.
- Yao-Hsien Wang, Hsueh Chun Wang, Rajalashmanan Eswaramoorthy, Je-ken Chang, Gwo-Jaw Wang, Mei Ling Ho
Development of the intra-articular injectable controlled-release PTH(1-34)/HA-MA hydrogel for osteoarthritis treatment.
2012 Annual Meeting of the Orthopaedic Research Society, San Francisco, USA, Feb 4-7, 2012.
- Yu-Fang Chang, Mei-Ling Ho, Je-Ken Chang, Gwo-Jaw Wang
The Study of Molecular Mechanisms of Alendronate on Enhancing Osteogenesis in Human Mesenchymal Stem Cells.
2012 Annual Meeting of the Orthopaedic Research Society, San Francisco, USA, Feb 4-7, 2012.
- Chau-Zen Wang, Tzu Hsiang Lin, Rajalashmanan Eswaramoorthy, Shun-Cheng Wu, Je-Ken Chang, Gwo-Jaw Wang, Mei Ling Ho
Development of injectable hyaluronan modified thermo-responsive hydrogel for adipose-derived stem cell based articular cartilage tissue engineering.
2012 Annual Meeting of the Orthopaedic Research Society, San Francisco, USA, Feb 4-7, 2012.
- Chau-Zen Wang, Gwo-Jaw Wang, Mei Ling Ho, Chia-Hsin Chen
Enhancement of transforming growth factor beta 1 and type I collagen expressions in tenocytes through low-magnitude vertical vibration stimulation.
2012 Annual Meeting of the Orthopaedic Research Society, San Francisco, USA, Feb 4-7, 2012.
- Jian-Chih Chen, Ru-Wei Lin, Rita Santos Wu, Yi-Shan Lin, Mei-Ling Ho, Je-ken Chang, Shao-Hung Hung, Yin-Chih Fu, Gwo-Jaw Wang, Chung-Hwan Chen
Intraperitoneal injection of (-)-epigallocatechin-3-gallate (EGCG) increases osteogenesis in ovariectomized rats.
2012 Annual Meeting of the Orthopaedic Research Society, San Francisco, USA, Feb 4-7, 2012.
- T.H. Lin, R. Eswaramoorthy, S.C. Wu, J.K. Chang, G.J. Wang, M.L. Ho
Development of Injectable Hyaluronan Modified Thermo-responsive Hydrogel for Adipose-derived Stem Cell Based Articular Cartilage Tissue Engineering.
2011 International Symposium on Recent Advances in Pluripotent Stem Cells & 7th Annual Meeting of TSSCR, Taipei, Oct 1-2, 2011.
- S.H. Chuang, C.J. Li, G.J. Wang, J.K. Chang, M.L. Ho
Cycloxygenase-2 Contributes to Osteogenic-differentiation on Murine Bone Marrow Mesenchymal Stem Cells.
2011 International Symposium on Recent Advances in Pluripotent Stem Cells & 7th Annual Meeting of TSSCR, Taipei, Oct 1-2, 2011.
- Mei-Ling Ho*, Rajalakshmanan Eswaramoorthy, Chia-Chi Chang, Shun-Cheng Wu, Je-Ken Chang, Gwo-Jaw Wang
Effect of controlled released PTH (1-34) encapsulated PLGA microspheres on treatment of early osteoarthritis in rat
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Chung-Hwan Chen*, Yi-Shan Lin, Shun-Cheng Wu, Shao-Hung Hung, Yin-Chih Fu, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho
Parathyroid hormone (1-34) improved knee osteoarthritis and function in rats with anterior cruciate ligament transaction
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Hui-Ting Chen, Shu-Chun Chuang, Song-Chen Huang, Mon-Guan Lee, Chung-Hwan Chen, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang*
Suppression of PPARγ enhances osteogenic differentiation and bone formation
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Shu-Chun Chuang, Ching-Ju Li, Chung-Hwan Chen, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang*
Estrogen Receptor contributed to simvastatin-stimulated osteogenic effects on osteogenic lineage cells
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Rajalakshmanan Eswaramoorthy, Hsueh-Chun Wang, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho
A pilot study on sustained release of PTH(1-34) from encapsulated injectable photocrosslinked hyaluronan hydrogel
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Ching-Ju Li, Li-Chi Tai, Cyong-Yue Liu, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho
Toona Sinensis enhanced osteosarcoma cell apoptosis via increasing Bax/Bcl-2 ratio
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Yan-Hsiung Wang, Pj Chou, Gwo-Jaw Wang, Mei-Ling Ho, Ming-Long Yeh, Chia-Hsin Chen
Suspension Cultured Human Adipose-Derived Stem Cells Maintain the Stemness Properties
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Ching-Ju Li, SHu-Chun Chuang, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho
Constitutively Expressed COX-2 Contributes to the Earlier Stage of Bone Growth in Cultured Calvaria
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Shun-Cheng Wu, Rajalakshmanan Eswaramoorthy, Je-Ken Chang, Yi-Shan Lin, Ya-Ting Yang, Gwo-Jaw Wang, Mei-Ling Ho
Molecular weight of hyaluronan alters its potential of chondrogenic effect on adipose derived stem cells
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Rajalakshmanan Eswaramoorthy, Tzu-Hsiang Lin, Shun-Cheng Wu, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho
A Novel hyaluronan thermoresponsive hydrogel for hADSCs transplantation in cartilage tissue engineering
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Ru-Wei Lin, Gwo-Jaw Wang
Anti?osteoporotic evaluation of certain indeno[1,2?c]quinoline derivatives derivatives
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Ru-Wei Lin, Gwo-Jaw Wang
Microporation?based Non?viral Gene Transfer BMP?2 Enhances Repair of Critical Size Bone Defects
2011 Annual Meeting of the Orthopaedic Research Society, Long Beach, USA, Jan 13-16, 2011.
- Ching-Ju Li, Je-Ken Chang, Gwo-Jaw Wang
Constitutively expressed cox-2 in osteoblasts positively regulates akt signal transduction via suppression of pten activity.
The Combined Academic Conference of 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) and 59th Annual Meeting of Taiwan Orthopedic Association (TOA), Taipei, Taiwan, Nov 4-7, 2010.
- Shun-Cheng Wu, Rajalakshmanan Eswaramoorthy, Je-Ken Chang, Yi-Shan Lin, Ya-Ting Yang, Gwo-Jaw Wang, Mei-Ling Ho
Molecular weight of hyaluronan alters its potential of chondrogenic effect on adipose derived stem cells.
The Combined Academic Conference of 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) and 59th Annual Meeting of Taiwan Orthopedic Association (TOA), Taipei, Taiwan, Nov 4-7, 2010.
- Ching-Ju Li, Li-Chi Tai, Cyong-Yue Liu, Je-Ken Chang, Gwo-Jaw Wang
Toona sinensis enhanced osteosarcoma cell apoptosis via increasing bax/bcl-2 ratio.
The Combined Academic Conference of 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) and 59th Annual Meeting of Taiwan Orthopedic Association (TOA), Taipei, Taiwan, Nov 4-7, 2010.
- HT Chen, SC Chuang, SC Huang, MJ Lee, CH Chen, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang
Suppression of pparγ enhances osteogenic differentiation and bone formation.
The Combined Academic Conference of 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) and 59th Annual Meeting of Taiwan Orthopedic Association (TOA), Taipei, Taiwan, Nov 4-7, 2010.
- Rajalakshmanan Eswaramoorthy, Chia-Chi Chang, Shun-Cheng Wu, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho
Effect of controlled released PTH (1-34) encapsulated PLGA microspheres on treatment of early osteoarthritis in rat.
The Combined Academic Conference of 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) and 59th Annual Meeting of Taiwan Orthopedic Association (TOA), Taipei, Taiwan, Nov 4-7, 2010.
- Chung-Hwan Chen, Yi-Shan Lin, Je-Ken Chang, Shau-Hung Hung, Shun-Cheng Wu, Yin-Chih Fu, Gwo-Jaw Wang, Mei-Ling Ho
Parathyroid hormone (1-34) improved knee osteoarthritis and function in rats.
The Combined Academic Conference of 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) and 59th Annual Meeting of Taiwan Orthopedic Association (TOA), Taipei, Taiwan, Nov 4-7, 2010.
- SH Chuang, CJ Li, CH Chen, GJ Wang, ML Ho, JK Chang
Estrogen receptor contributed to simvastatin-stimulated osteogenic effects on osteogenic lineage cells.
The Combined Academic Conference of 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) and 59th Annual Meeting of Taiwan Orthopedic Association (TOA), Taipei, Taiwan, Nov 4-7, 2010.
- Yin-Chih Fu, Chih-Chun Lin, Je-Ken Chang, Chung-Hwan Chen, Kao-Chi Chung, Gwo-Jaw Wang, Mei-Ling Ho
A novel single pulsed electromagnetic field stimulates the osteogenesis and angiogenesis - in vitro and in vivo study.
The Combined Academic Conference of 16th Triennial Congress of Asia Pacific Orthopaedic Association (APOA) and 59th Annual Meeting of Taiwan Orthopedic Association (TOA), Taipei, Taiwan, Nov 4-7, 2010.
- Mei-Ling Ho, Chau-Zen Wang, Shih-Mao Chen, Chung-Hwan Chen, Chih-Kuang Wang, Gwo-Jaw Wang, Je-Ken Chang
Local Delivery of Alendronate Enhances Human Adipose Derived Stem Cell Based Bone Regeneration.
7th Combined Meeting of the Orthopaedic Research Societies, Kyoto, Japan, Oct 16-20, 2010.
- Chih-Kuang Wang, Yan-Hsung Wang, Shao-Ping Lo, Bing-Hung Chen, Gwo-Jaw Wang
Novel Cationic Nanoparticles of Bis(PLGA-PEG)-qDETA Copolymers for Gene Transfection.
37th Annual Meeting & Exposition of the Controlled Release Society, Portland, USA, Jul 10-14. 2010.
- Ching-Ju Li, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho
COX-2 Involves in the Regulation of Akt/FOXO-3a/p27Kip1 Signal transduction in Human Osteoblasts.
The 56th Annual Meeting of Orthopaedic Research Society, New Orleans, USA, Mar 6-9, 2010.
- SC Wu, E. Rajalakshmanan, JKChang, GJ Wang, ML Ho
The hyaluronan pretreatment promote chondrogenic differentiation of adipose derived stem cell in a fibrin hydrogel
The 56th Annual Meeting of Orthopaedic Research Society, New Orleans, USA, Mar 6-9, 2010.
- RW Lin, YH Wang, HC Chu, SC Lai, HC Lin, JK Chang, ML Ho, GJ Wang
Bone regeneration in critical size defect by hBMSCs mediated BMP-2 non-viral gene transfer.
The 56th Annual Meeting of Orthopaedic Research Society, New Orleans, USA, Mar 6-9, 2010.
- RW Lin, ML Ho, GJ Wang
Anti-osteoporotic evaluation of certain 3-amino-2-hydroxypropoxyisoflavone derivatives.
The 56th Annual Meeting of Orthopaedic Research Society, New Orleans, USA, Mar 6-9, 2010.
- E. Rajalakshmanan, SC Wu, LC Tai, JK Chang, GJ Wang, ML Ho
Transplantation of hADSCs combined PLGA cross-linked alendronate enhances bone repair in rats.
The 56th Annual Meeting of Orthopaedic Research Society, New Orleans, USA, Mar 6-9, 2010.
- SC Wu, E. Rajalakshmanan, JK Chang, GJ Wang, ML Ho
The hyaluronan pretreatment promote chondrogenic differentiation of human adipose derived stem cell in a fibrin hydrogel
2010 Annual Meeting of Formosa Association of Regenerative Medicine Scientific Program, Taipei, Taiwan, Feb27-28, 2010.
- E. Rajalakshmanan, SC Wu, LC Tai, JK Chang, GJ Wang, ML Ho
Effect of PLGA cross linked alendronate microspheres on osteogenesis of adipose derived stem cell.
2010 Annual Meeting of Formosa Association of Regenerative Medicine Scientific Program, Taipei, Taiwan, Feb27-28, 2010.
- E. Rajalakshmanan, CC Chang, SC Wu, LC Tai, JK Chang, GJ Wang, ML Ho
In-vitro study on controlled release of PTH(1-34) from encapsulated Poly(Lactic-Glycolic)Acid microspheres.
2010 Annual Meeting of Formosa Association of Regenerative Medicine Scientific Program, Taipei, Taiwan, Feb27-28, 2010.
- (Invited speaker) Gwo-Jaw Wang
(1) Association SNPs in Osteonecrosis patients with SLE in Taiwanese and it’s potential use for early detection
(2) Statin prevents steroid induced Osteonecrosis of the femoral head
(3) Effect of Alendronate on Femoral Head Collapse in Non-traumatic Osteonecrosis (A Randomized Study)
The 15th International Symposiumon Bone Circulation of Association Research Circulation Osseous and The 37th Annual Meeting of Japanese Society for Joint Disease, Shinyokohama, Yokohama, Japan, Nov 17-19, 2009.
- 林摯鈞, 戴莉琦, 陳崇桓, 張瑞根, 王國照, 何美泠
A novel single pulsed electromagnetic field stimulates the osteogenesis and angiogenesis in vitro and in vivo study.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 24-25, 2009.
- 路卡曼, 吳順成, 戴莉琦, 張瑞根, 王國照, 何美泠
Effects of PLGA cross linked Alendronate on Osteogenesis of adipose derived stem cell.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 24-25, 2009.
- 戴莉琦, 傅尹志, 張瑞根, 王國照, 何美泠
Effect of local delivery of control release simvastation/PLGA carried on bone healing.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 24-25, 2009.
- 張家齊, 王國照, 何美泠
Fabrication and characterization of poly(lactic-co-glycolic acid) microspheres carrying parathyroid hormone(1-34).
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 24-25, 2009.
- 吳順成, 張瑞根, 王志光, 王國照, 何美泠
Hyaluronan-enriched microenvironment induces chondrogenic differentiation of human adipose derived stem cells.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 24-25, 2009.
- 洪永豊, 張瑞根, 何美泠, 王國照, 王昭仁
The role of discoidin domain receptors in chondrogenesis of human mesenchymal stem cells.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 24-25, 2009.
- 張玉芳, 陳健馥, 陳世茂, 張瑞根, 王國照, 何美泠
A new synthetic isoflavonoid, TCH2972, enhances osteogenesis in cultured human adipose derived stem cells.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 24-25, 2009.
- 陳世茂, 張瑞根, 陳健馥, 張玉芳, 王國照, 何美泠
Effect of alendronate on enhancing osteogenesis of human adipose derived stem cells in tissue engineering for bone repair.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 24-25, 2009.
- 林怡珊, 林摯鈞, 王國照, 鍾高基, 張瑞根, 何美泠
The effect of electromagnetic field stimulation on chondrogenic differentiation of human adipose-derived stem cells.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 24-25, 2009.
- 李靜如, 張瑞根, 周佳璇, 王國照, 何美泠
Cycloxygenase-2 involves in Akt/FOXO-3a/p27kip1 signal transduction and regulates proliferation and differentiation in human osteoblasts.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 24-25, 2009.
- (Invited speaker) Gwo-Jaw Wang
Effect of Alendronate on Femoral Head Collapse in Non-traumatic Osteonecrosis (A Randomized Study)
The Hip Society Summer Meeting, Palo Alto, California, U.S.A. , Sep 24-26, 2009.
- Yu-Fang Chang, Chien-Fu Chen, Shin-Mon Chen, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho
A new synthetic isoflavonoid, TCH2972, enhances osteogenesis in cultured human adipose derived stem cells.
The 36th Congress of the International Union of Physiological Sciences, Kyoto, Japan, Jul 28-Aug 1, 2009.
- Chau-Zen Wang, Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Che-Yu Hsu
A time course and dose-dependent effect of alendronate on the osteogenic differentiation of human bone marrow derived stem cells.
The 36th Congress of the International Union of Physiological Sciences, Kyoto, Japan, Jul 28-Aug 1, 2009.
- Chih Chun Lin, Yi Shan Lin, Gwo Jaw Wang, Kao Chi Chung, Mei Ling Ho
A novel single pulsed electromagnetic field stimulates the osteogenesis of human bone marrow derived mesenchymal stem cells.
The 36th Congress of the International Union of Physiological Sciences, Kyoto, Japan, Jul 28-Aug 1, 2009.
- Yi-Shan Lin, Chin-Chun Lin, Gwo-Jaw Wang, Kao-Chi Chung, Je-Ken Chang, Mei-Ling Ho
The effect of electromagnetic field stimulation on chondrogenic differentiation of human adipose-derived stem cells.
The 36th Congress of the International Union of Physiological Sciences, Kyoto, Japan, Jul 28-Aug 1, 2009.
- Shih-Mao Chen, Je-Ken Chang, Chien-Fu Chen, Yu-Fang Chang, Gwo-Jaw Wang, Mei-Ling Ho
Effect of alendronate on enhancing osteogenesis of human adipose derived stem cells in tissue engineering for bone repair.
The 36th Congress of the International Union of Physiological Sciences, Kyoto, Japan, Jul 28-Aug 1, 2009.
- Ching-Ju Li, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho
Cycloxygenase-2 involves in AKT/ FOXO-3a/p27kip1 signal transduction and regulates proliferation and differentiation in human osteoblasts.
The 36th Congress of the International Union of Physiological Sciences, Kyoto, Japan, Jul 28-Aug 1, 2009.
- Ching-Ju Li, Je-Ken Chang, Chia-Hsuan Chou, Gwo-Jaw Wang, Mei- Ling Ho
The PI3K/AKT/FOXO-3a/p27kip1 pathway contribute to anti-inflammatory drug caused suppression of proliferation in human osteoblasts.
The 36th Congress of the International Union of Physiological Sciences, Kyoto, Japan, Jul 28-Aug 1, 2009.
- Chung-Hwan Chen, Mei-Ling Ho, Je-Ken Chang, Shao-Hung Hung, Gwo-Jaw Wang
(-)-Epigallocatechin-3-gallate(EGCG) enhahces osteogenesis in human bone marrow stromal cells.
The 55th Annual Meeting of Orthopaedic Research Society, Las Vegas, USA, Feb 22-25, 2009.
- Ching-Ju Li; Je-Ken Chang; Chia-Hsuan Chou; Gwo-Jaw Wang; Mei-Ling Ho
Anti-inflammatory Drugs Enhance p27Kip1 Expression via PI3K/Akt/FoxO-3a Pathway in Human Osteoblasts: A Mechanism of Anti-inflammatory Drug Effect on Proliferation.
The 55th Annual Meeting of Orthopaedic Research Society, Las Vegas, USA, Feb 22-25, 2009.
- Yan-Hsiung Wang, Mon-Juan Lee, Je-Ken Chang, Mei-Ling Ho, Hai-Chang Chu, Shu-Chin Lai, Gwo-Jaw Wang
Transfection of Human Bone Marrow Stromal Cells Using Microporation, an Effective Non-Viral Transfection Technique.
The 55th Annual Meeting of Orthopaedic Research Society, Las Vegas, USA, Feb 22-25, 2009.
- Chih-Chun Lin, Yi-Shan Lin, Gwo-Jaw Wang, Kao-Chi Chung, Mei-Ling Ho
A Novel Single Pulsed Electromagnetic Field Stimulates the Osteogenesis of Human Bone Marrow Derived Mesenchymal Stem Cells.
The 55th Annual Meeting of Orthopaedic Research Society, Las Vegas, USA, Feb 22-25, 2009.
- Ching-Hua Yeh, Je-Ken Chang, Mei-Ling Ho, Chung-Hwan Chen, Gwo-Jaw Wang
Different differentiation potential of stroma cells from patients with and without osteonecrosis.
The 55th Annual Meeting of Orthopaedic Research Society, Las Vegas, USA, Feb 22-25, 2009.
- Yu-Fang Chang, Chien-Fu Chen, Shih-Mao Chen, Je-Ken Chang, Gwo-Jaw Wang, Mei-Ling Ho
A new synthetic isoflavonoid, TCH2972, enhances osteogenesis in cultured human adipose derived stem cells.
The 55th Annual Meeting of Orthopaedic Research Society, Las Vegas, USA, Feb 22-25, 2009.
- Mei-Ling Ho, Shun-Cheng Wu, JK Chang, CK Wang, GJ Wang
Hyaluronan-Enriched Microenvironment Induces Chondrogenic Differentiation of Human Adipose Derived Stem Cells
The 55th Annual Meeting of Orthopaedic Research Society, Las Vegas, USA, Feb 22-25, 2009.
- Ru-Wei Lin, Mei-Ling Ho, Yan-Hsiung Wang, Ih-Sheng Chen, Gwo-Jaw Wang
Green tea polyphenols inhibit osteoclastic differentiation.
The 55th Annual Meeting of Orthopaedic Research Society, Las Vegas, USA, Feb 22-25, 2009.
- Yi-Shan Lin, Chih-Chun Lin, Gwo-Jaw Wang, Kao-Chi Chung, Shun-Cheng Wu, Je-Ken Chang, Mei-Ling Ho
The Effect of Electromagnetic Field Stimulation on Chondrogenic Differentiation of Human Adipose-Derived Stem Cells.
The 55th Annual Meeting of Orthopaedic Research Society, Las Vegas, USA, Feb 22-25, 2009.
- 李孟娟, 陳惠亭, 陳宜慧, 王欣誼, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang
The bone repair and formation potentials of adipose tissue-derived stem cells.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 25-26, 2008.
- 李孟娟, 黃昭敏, 陳惠亭, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang
PPARg mRNA interference may promote osteogenic gene expression of adipose tissue-derived stem cells.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 25-26, 2008.
- 陳世茂, Je-Ken Chang, 陳健馥, 張玉芳, Gwo-Jaw Wang, Mei-Ling Ho
Effects of Alendronate on enhancing osteogenesis of human adipose derived stem cells in tissue engineering for bone repair.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 25-26, 2008.
- 李靜如, Je-Ken Chang, 周佳璇, Gwo-Jaw Wang, Mei-Ling Ho
Anti-inflammatory drugs enhance p27Kip1 expression via PI3K/Akt/FOXO-3a pathway in human osteoblasts: the machinery of anti-inflammatory drugs on proliferation.
Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, Oct 25-26, 2008.
- Huang W.T., Lin S.R., Wang G.J.
Association SNPs in Osteonecrosis patients with SLE in Taiwanese and it’s potential use for early detection.
The Closed Meeting of the Hip Society, Chicago, USA, Sep 25-27, 2008.
- Lu CM, Chen YL, Wang GJ, Ho ML, Tzeng CC
Synthesis and Anti-osteoporotic Evaluations of Certain 3-Amino-2-hydroxypropoxyisoflavone Derivatives.
The 6th International Symposium for Chinese Medicinal Chemists (ISCMC 2008), Shanghai, China, Jul 28-Aug 2, 2008.
- Hui-Ting Chen, Mei-Ling Ho, Mon-Juan Lee, Chung-Hwan Chen, Hsin-I Wang, Yi-Hui Chen, Gwo-Jaw Wang,
Je-Ken Chang
Osteogenic potential of human adipose tissue-derived stem cells in the elderly osteoporotic population.
Sixth ISSCR Annual Meeting, Philadelphia, USA, Jun 11-14, 2008.
- Ching-Ju Li , Je-Ken Chang, Gwo-Jaw Wang, Chia-Hsuan Chou, Mei-Ling Ho
Anti-inflammatory Drugs Enhance P27Kip1 Expression via PI3K/Akt Pathway in Human Osteoblasts.
The 54th Annual Meeting of Orthopaedic Research Society, San Francisco, USA, Mar 2-5, 2008.
- Chih-Chun Lin, Kao-Chi Chung, Gwo-Jaw Wang, Mei-Ling Ho
Effect of Electromagnetic Field Stimulation on Proliferation and Osteogenic Differentiation of Human Mesenchymal Stem Cells.
The 54th Annual Meeting of Orthopaedic Research Society, San Francisco, USA, Mar 2-5, 2008.
- Ru-Wei Lin, Mei-Ling Ho, Yan-Hsiung Wang, Ih-Sheng Chen, Gwo-Jaw Wang
Green tea catechin (-)-epigallocatechin-3-gallate inhibits bone resorption via suppression of nf-κb.
The 54th Annual Meeting of Orthopaedic Research Society, San Francisco, USA, Mar 2-5, 2008.
- Yan-Hsiung Wang, Mei-Ling Ho, Hai-Chang Chu , Shu-Chin Lai, Gwo-Jaw Wang
Microporation- A valuable transfection method for gene expression in human adipose tissue-derived stem cells
The 54th Annual Meeting of Orthopaedic Research Society, San Francisco, USA, Mar 2-5, 2008.
- Ching-Hua Yeh, Je-Ken Chang, Yan-Hsiung Wang, Mei-Ling Ho, Gwo-Jaw Wang
Ethanol Suppresses Wnt/β-catenin Signaling on Human Bone Marrow Stroma Cells
The 54th Annual Meeting of Orthopaedic Research Society, San Francisco, USA, Mar 2-5, 2008.
- Mei-Ling Ho, Chain-Fu Chen, Yu-fang Chang, Che-Yu Hsu, Mao-Shi Chen, Je-Ken Chang, Gwo-Jaw Wang
Alendronate enhnces osteogenic differrentiation in human mesenchymal stem cells derived from bone marrow and adipose tissue
The 54th Annual Meeting of Orthopaedic Research Society, San Francisco, USA, Mar 2-5, 2008.
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列出全部論文發表(doc檔)
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執行中之研究計畫： |
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計 畫 名 稱 |
計畫內
擔任之工作 |
起迄年月 |
補助或
委託機構 |
經 費 |
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研發應用於骨與軟骨再生醫學之創新藥物、生醫材料及醫療器材
Development of Novel Drugs, Biomaterials and Medicine Devices for Bone and Cartilage Regeneration
(經濟部學界科專計畫)
100-EC-17-A-19-S1-176
(A1)PTH(1-34)製劑治療退化性關節炎之臨床前試驗
(A2)攜帶PTH(1-34)控制釋放載體之創新研發
(B1)含simvastatin 控放型骨引導藥物醫材之臨床前試驗
(B2)兼具骨引導與骨傳導之骨材之創新研發
(Core)高雄醫學大學骨科學研究中心 |
顧問 |
2011.11-
2016.10 |
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75,000,000
15,000,000/yr
(A1)
(I)3,876,000
(A2)
(I)2,091,000
(B1)
(I)3,290,000
(B2)
(I)2,119,000
(Core)
(I)3,624,000 |
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骨與軟骨再生之創新醫藥技術研發
Development of Innovative Techniques for Regeneration of Bone & Cartilage
97-EC-17-A-17-S1-041
98-EC-17-A-17-S1-041
99-EC-17-A-17-S1-041
(經濟部學界科專計畫第二期)
(A1) 研發與應用非病毒基因轉殖治療嚴重骨缺損與骨質壞死症
(A2) 促進移植幹細胞骨靶向能力之研發
(A3) 治療退化性關節炎及關節軟骨再生之創新研發
(B1) 治療骨質疏鬆症新藥研發
(B2) 新型可注式溫感水膠支架之研發-應用於骨及軟骨之重建(Core)核心實驗室
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總主持人/
A1
子計畫主持人 |
2008.07-
2011.06 |
經濟部 |
59,000,000
(總)
(I)4,540,000
(II)2,512,000
(III)2,522,000
(A1)
(I)2,563,000
(II)2,748,000
(III)2,913,000
(A2)
(I)2,551,000
(II)2,748,000
(III)2,913,000
(A3)
(I)2,562,000
(II)2,748,000
(III)2,913,000
(B1)
(I)3,217,000
(II)2,748,000
(III)2,913,000
(B2)
(I)2,563,000
(II)2,748,000
(III)2,913,000
(Core)
(I)2,003,000
(II)2,748,000
(III)2,913,000 |
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開發促進骨生成之化學藥劑及物理治療
Development of Chemical and Physical Agents Enhancing Bone Formation
NHRI-EX96-9615EP
NHRI-EX97-9615EP
NHRI-EX98-9615EP
(國衛院整合性醫藥衛生計畫PPG)
(Proj-1) Effects of Green Tea Catechins on Osteogenesis
(Proj-2) Enhancement of osteogenesis through PPAR��2 mRNA interference system in human mesenchymal stem cells
(Proj-3) The Study of Molecular Biologic Mechanisms of Mevalonate Pathway Blockers on Osteogenesis
(Proj-4) Investigation of NMDA receptor mediation in osteogenesis after physical stimulus: from signal transduction to gene regulation
(Core A) Orthopaedic Research Center at Kaohsiung Medical University |
總主持人/
Proj-1
子計畫主持人 |
2007.01-
2009.12 |
國衛院 |
28,975,000
(I)9,616,000
(II)9,682,000
(III)9,677,000總主持人運用費用
(I)625,000
(II)959,000
(III)979,000
(Proj-1)
(I)1,950,000
(II)1,950,000
(III)1,900,000
(Proj-2)
(I)1,950,000
(II)1,980,000
(III)1,930,000
(Proj-3)
(I)1,950,000
(II)1,980,000
(III)1,900,000
(Proj-4)
(I)1,950,000
(II)1,950,000
(III)1,900,000
(Core A)
(I)1,191,000
(II)863,000
(III)1,068,000 |
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